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Life Sciences

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Published yearly: 

4 Issues

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ISSN: 2320-964X (Online) 

ISSN: 2320-7817  (Print)

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Editor-in-Chief

Dr. Santosh Pawar 


INDEXED IN

REVIEW ARTICLE

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Int. Journal of Life Sciences, 2016; 4(1):151-158 |  Available online, April 13, 2016

Stem Cells: Spatio-temporal Diversity and Therapeutic Applications

 

Chaudhary Pankaj Kumar1, Mishra Kamlesh Kumar2 and Chaudhary Jitendra Kumar*

1Department of Zoology, School of Life Sciences, Dr. B. R. Ambedkar University, Agra, India

2Department of Biochemistry, University of Allahabad, Allahabad, India

*Corresponding Author: Dr. Jitendra Kumar Chaudhary, Assistant  Professor, Department of Zoology, Shivaji College, University of Delhi, New Delhi,  India

Email: jnujitendra@gmail.com

 

Received: 10.02.2016   |   Revised : 08.03.2015 |  Accepted: 23.03.2016  |    Published : 13.04.2016

Stem cells are cells of special kind with immense self-renewal and differentiation/trans-differentiation potential. Therefore, they are capable of providing various functional, structural and homeostatic supports to almost all kind of tissues and organs throughout the life. They are pervasive, and found to reside in almost all the organs, especially within the organ-specific anatomical niche so as to provide optimal access for better performance and tissue homeostasis as well as can be used as cellular backup, help repair damage and maintenance of concerned organs. These organ’s in-built niches and microenvironments help maintain substantial repertoire of stem cells throughout life of multicellular organisms. These cellular repertoires of stem cells, however, decline with the age and deteriorating health status of an individual. Furthermore, meticulous research works of several decades have broadened and deepened our horizon of multidimensional understanding about the pervasive cellular intercourse observed between stem and non-stem cells at the cellular, molecular and biochemical levels. Stem cells have immense potential of intracellular, such as autocrine and intercellular, such as paracrine, communications, as well as communications with the genetically, structurally and functionally distinct cell types located somewhere else in the body. In this work, we have tried to throw light upon such a structurally and functionally kaleidoscopic cell entity, with special emphasis on their spatio-temporal diversity and therapeutic relevance in ever changing disease dynamics at molecular and cellular levels.      

 

Keywords:Stem cells, anatomical niche, paracrine, autocrine, cellular intercourse, spatio-temporal diversity, therapeutic relevance.

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Editor: Dr. Arvind Chavhan

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Cite this article as:

Chaudhary Pankaj Kumar, Mishra Kamlesh Kumar and Chaudhary Jitendra Kumar (2016) Stem Cells: Spatio-temporal Diversity and Therapeutic Application. International J. of Life Sciences, 4(1): 151-158.

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Acknowledgements

*Author extends a deep sense of gratitude to the Department of Zoology, Shivaji College, University of Delhi

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Competing Interests: Authors have declared that no competing interest exists

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Copyright: © 2016 | Author(s), This is an open access article under the terms of the Creative Commons Attribution-Non-Commercial - No Derivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.


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    INTERNATIONAL JOURNAL OF

    LIFE SCIENCES

    Print ISSN : 2320-7817 

    Online ISSN:2320-964X

    UGC Approved Journal No. 48951


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