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Published yearly: 

4 Issues

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ISSN: 2320-964X (Online) 

ISSN: 2320-7817  (Print)

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Dr. Santosh Pawar 


INDEXED IN

ORIGINAL ARTICLE

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Int. Journal of Life Sciences, 2016; 4(1):63-70 |  Available online, April 11, 2016

Effects of sunlight exposure vs. commercial vitamin D supplementation on the bone health of

vitamin D deficient rats

 

Mahmoud Mustafa Ali Abulmeaty MD1,2 

1King Saud University, Department of Community health sciences, Collage of Applied Medical sciences, Riyadh, KSA.

2Zagazig University, Obesity research and management unit, Department of Medical Physiology, Faculty of Medicine, Zagazig, Egypt.

Email: Dr.abulmeaty@gmail.com  |  mabulmeaty@ksu.edu.sa

Received: 08.03.2016   |  Accepted: 21.03.2016   |   Published : 11.04.2016

This study compared sun exposure with commercial vitamin D3 supplementation in restoring bone health in a vitamin D deficient rat model. 35 healthy weaned male albino rats were divided into two groups. Vitamin D deficient rats (n=21) were subdivided into: an Sd group (n=7) that was directly exposed to sun-light, a Tt group (n=7) that was treated with commercial vitamin D3 with oil, and a Ct group (n=7) that was treated with canola oil without vitamin D.  Normal diet fed rats were subdivided into: a Cs group (n=7)  that was exposed to sunlight and fed a normal vitamin D chow and a control (C) group(n=7). Plasma 25 hydroxy vitamin D3, parathyroid hormone, calcium, phosphorus levels and the enzymatic activity of alkaline phosphatase were estimated and femur bones were used to prepare histopathological sections. The sun-exposed groups showed a significant reduction in levels of parathyroid hormone (67.69±13.18 vs 86.05±9.67 pg/mL, P < 0.05) in addition to an improvement of osteoid area and a reduction of trabecular separation in the bone sections. In a conclusion, sun-exposure have a more positive effect on bone structure and hormones that control bone mass rather than normalization of vitamin D.


Key words: Sunlight exposure, vitamin D supplementation, vitamin D deficiency, bone histology.

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Editor: Dr. Arvind Chavhan

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Cite this article as:

Mahmoud Mustafa Ali Abulmeaty MD (2016) Effects of sunlight exposure vs. commercial vitamin D supplemen-tation on the bone health of vitamin D deficient rats.  International J. of Life Sciences, 4(1): 63-70.

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Acknowledgements

The author would like to extend his sincere appreciation to the Deanship of Scientific Research at King Saudi University, KSA for its funding thisresearch group NO(RGP- 193).

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Copyright: © 2016 | Author(s), This is an open access article under the terms of the Creative Commons Attribution-Non-Commercial - No Derivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.


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    INTERNATIONAL JOURNAL OF

    LIFE SCIENCES

    Print ISSN : 2320-7817 

    Online ISSN:2320-964X

    UGC Approved Journal No. 48951


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