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Life Sciences

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Published yearly: 

4 Issues

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ISSN: 2320-964X (Online) 

ISSN: 2320-7817  (Print)

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Editor-in-Chief

Dr. Santosh Pawar 


INDEXED IN

RESEARCH REPORT

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Int. Journal of Life Sciences, 2016; 4(2):289-292 |  Available online,July 23, 2016

Generation of Induced Pluripotent Stem Cells (iPSCs) through Cellular Reprogramming

  

Chaudhary Pankaj Kumar1  and Chaudhary Jitendra Kumar*

 

1Department of Zoology, School of Life Sciences, Dr. B. R. Ambedkar University, Agra, India

*Corresponding Author: Dr. Jitendra Kumar Chaudhary, Assistant Professor, Department of Zoology, Shivaji College, University of Delhi, New Delhi, India

Email: jnujitendra@gmail.com

 

Received: 03.05.2016   |   Accepted: 25.06.2016   |  Published : 23.07.2016

 

Induced pluripotent stem cells (iPSCs) are primarily derived from completely differentiated somatic cells or non-stem cells following molecular induction and cellular reprogramming. Molecular induction, leading to formation of iPSCs, has successfully been accomplished at multiple molecular hierarchies of biomolecules, including DNA, RNA, and Protein, and even using small organic inducer molecules like non-steroid anti-inflammatory drug, Nabumetone, the anticancer drug, 4-hydroxytamoxifen and so on. Such molecular induction leads to almost complete reversal of cellular machinery from differentiated state to undifferentiated state, restoring the immense biological potential which is considerably similar to Embryonic Stem cells (ESCs). This scientific breakthrough and tremendous accomplishment has given researchers rays of hope and equipped them to carry out various preclinical and clinical trials and translate the trial-based findings to design cure for various dreaded and degenerative diseases. Furthermore, its implication also transcends the various biological boundaries wherein it can be employed to slow down the physiological degeneration, such as aging, occurring owing to the cellular senescence and stem cell exhaustion. Besides, iPSCs can also help in understanding the normal development process as well as underlying mechanism leading to diseases. Pursuing research in this direction, various promising results have already been achieved which need to be consolidated and further extended to the next level of translational research. The uses of iPSCs is not only limited to cell-based therapy but have also been extended to the level of biological manufacturing, therapeutic cloning, and biosynthesis wherein several biomolecules, including growth hormones, chemokines, immunological molecules, such as interferon and interleukin of therapeutic significance are being synthesized by iPSCs-derived cells and organs. Moreover, iPSCs-derived cells and tissues are being used for toxicity testing and drug development.

 

Keywords: Induced Pluripotent Stem Cells, Molecular Induction, and Cellular reprogramming, Embryonic Stem Cells, Translational Research

 

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Editor: Dr. Arvind Chavhan

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Cite this article as:

Chaudhary Pankaj Kumar1, Chaudhary Jitendra Kumar (2016) Generation of Induced Pluripotent Stem Cells (iPSCs) through Cellular Reprogramming, International J. of Life Sciences, 4(2): 289-292.

 

Acknowledgements

Author extends a deep sense of gratitude to the Department of Zoology, Shivaji College, University of Delhi.

 

Competing Interests: Authors declare that no competing interest exists. 

 

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Copyright: © 2016 | Author(s), This is an open access article under the terms of the Creative Commons Attribution-Non-Commercial - No Derivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.


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    INTERNATIONAL JOURNAL OF

    LIFE SCIENCES

    Print ISSN : 2320-7817 

    Online ISSN:2320-964X

    UGC Approved Journal No. 48951


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