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Published yearly: 

4 Issues

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ISSN: 2320-964X (Online) 

ISSN: 2320-7817  (Print)

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Editor-in-Chief

Dr. Santosh Pawar 


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Int. Journal of Life Sciences, 2016; 4(2):302-305 |  Available online,July 23, 2016

Screening of  Acetylcholinesterase inhibitors by Moringa olifera

 

 

Raje  Sharayu and  Mestry Asmita

 

Department of Botany. Bhavans College Andheri(W)

Email: suhassharayu@gmail.com  |  mestryasmita02@gmail.com

 

Received: 09.01.2016  |  Revised : 03.03.2016  |  Accepted: 25.06.2016   |  Published : 23.07.2016

 

Acetylcholinesterase (AChE) is an enzyme involved in the breakdown of the neurotransmitter acetylcholine into acetic acid and choline. Inhibition of Acetylcholinesterase is needed for deceleration of neurodegeneration in Alzheimer’s, Parkinson’s and other neurodegenerative diseases. Plants are known to contain Acetylcholinesterase inhibitors.The methanolic extracts  of Moringa olifera leaves were checked for Acetylcholinesterase inhibition on the acetylcholinesterase from brain homogenate of Danio rerio. The activity of the enzyme  in-vitro and in-vivo conditions. In our investigations the extract from the plant showed a reduction in the Acetylcholinesterase activity. Under in-vitro conditions and in-vivo conditions the activity of Acetylcholinesterase dropped by 29.26%  and 34.26% respectively.

 

 Keywords: Alzheimer’s Disease, Acetylcholinesterase, Inhibition, Zebrafish, Plant Extracts.

 

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Editor: Dr. Arvind Chavhan

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Cite this article as:

Raje  Sharayu and  Mestry Asmita (2016)Screening of  Acetylcholines- terase inhibitors by Moringa olifera  International J. of Life Sciences, 4(2): 302-305

 

 

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Copyright: © 2016 | Author(s), This is an open access article under the terms of the Creative Commons Attribution-Non-Commercial - No Derivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.


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    INTERNATIONAL JOURNAL OF

    LIFE SCIENCES

    Print ISSN : 2320-7817 

    Online ISSN:2320-964X

    UGC Approved Journal No. 48951


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