Image description

Life Sciences

Image description

Published yearly: 

4 Issues

______________________

ISSN: 2320-964X (Online) 

ISSN: 2320-7817  (Print)

______________________

Editor-in-Chief

Dr. Santosh Pawar 


INDEXED IN

ORIGINAL ARTICLE

___________________________________________________________________________________

Int. Journal of Life Sciences, 2016; 4(2):185-192 |  Available online,July 23, 2016

S6 peptide derived from KvAP channel shows marked differences in secondary structure after mutation- a computational approach

 

 

Chetan Malik1*, Rajan Shrivastava2, Subhendu Ghosh2, Hasan SS1

 

1Department of Life Science, School of Sciences, Indira Gandhi National Open University, New Delhi, 110068, India

2Department of Biophysics, University of Delhi South Campus, New Delhi, 110021, India

*Corresponding author: Email: dfinechetan@gmail.com  |   Phone +919818994921

 

Received: 16.05.2016   |    Accepted: 10.06.2016   |   Published : 23.07.2016

KvAP is a widely studied potassium channel from bacterium Aeropyrum pernix. It is composed of six trans-membrane domains ranging from S1 to S6. Out of these six domains, S6 is the domain through which transfer of ions occurs. We have analyzed the structural differences in the s6 domains after mutating more hydrophobic amino acids with less hydrophobic amino acids. The computational studies suggest that there is a change in the secondary structures of protein which leads to its altered functioning. The RMSD (Root mean square distance) of the peptides were calculated and significant differences were observed in Ramachandran plot. The computational analysis complements the earlier published results.

 

Keywords: KvAP channel, Secondary structure, Ramachandran plot, RMSD (Root Mean Square Deviation), Hydrophobicity.


_________________________________________________________________________

Editor: Dr. Arvind Chavhan

___________________________________________________________________________________ 

Cite this article as:

Chetan Malik, Rajan Shrivastava, Subhendu Ghosh, Hasan SS (2016) S6 peptide derived from KvAP channel shows marked differences in secondary structure after mutation- a computational approach, International J. of Life Sciences, 4 (2): 185-192.

 

_________________________________________________________________________

Copyright: © 2016 | Author(s), This is an open access article under the terms of the Creative Commons Attribution-Non-Commercial - No Derivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.


_________________________________________________________________________

IJLSCI EVENTS

National Conference on

ADVERTISEMENT

 
















    INTERNATIONAL JOURNAL OF

    LIFE SCIENCES

    Print ISSN : 2320-7817 

    Online ISSN:2320-964X

    UGC Approved Journal No. 48951


    EDITORIAL OFFICE

    46, Guruwandan, Jawahar Nagar, 

    VMV Road, Amravati- 444604

    Maharashtra, India.

    Tel  + 91- 9970559438

    Email: editor@ijlsci.in