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Life Sciences

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Published yearly: 

4 Issues

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ISSN: 2320-964X (Online) 

ISSN: 2320-7817  (Print)

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Dr. Santosh Pawar 


INDEXED IN

ORIGINAL ARTICLE

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Int. Journal of Life Sciences, 2016; 4(2):203-206 |  Available online,July 23, 2016

Alleviation of  Ibuprofen  induced  Nephrotoxicity  by  vitamin supplementations

                      

 

Kalaivani B1*, Thangapandiyan K2 and Vanithakumari G2

 

1Department of Zoology, Sri Sarada College for Women (Autonomous), Salem – 636 016, Tamil Nadu, India.

2Department of Zoology, Bharathiyar University, Coimbatore - 641 046.

*Corresponding author Email: kalai03win@yahooo.co.in


Received: 02.05.2016   |    Accepted: 15.06.2016   |   Published : 23.07.2016

The aim of the present study was to investigate the impact of the combined administration of vitamin B complex and ‘C’ on ibuprofen induced nephrotoxicity. Male albino rats were subdivided into five groups: the first was a control group, the second and third received Ibuprofen at a low and high dose of 1.5 mg and 3 mg/ 100g body weight / day respectively for 7 days, the fourth group received high dose and vitamin supplementation (B complex and C) at a dosage of ml /100g body weight, the fifth group rats received high dose (3 mg) of ibuprofen for seven days followed by withdrawal of drug for a further seven days. No significant changes were observed in the histopathology of kidney tissues in the control rats. The Ibuprofen treatment affects the histopathology of kidney. Low dose treatment group, minor glomerular abnormality (increase in size). In high dose also increase in size of glomerulus was observed. Many proximal convoluted tubules showed hydropic changes, coagulation necrosis and degeneration with inflammation treated group showed normalcy of the histoarchitecture of the kidney. Regeneration was started in the withdrawal group.

 

Key words : Ibuprophen, nephrotoxicity, B complex, Vitamin C.


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Editor: Dr. Arvind Chavhan

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Cite this article as:

Kalaivani B, Thangapandiyan K and Vanithakumari G (2016) Alleviation of Ibuprofen induced Nephrotoxicity by vitamin supplementations, International J. of Life Sciences, 4(2): 203-206.

 

Acknowledgement

With the sense of high resolve, the authors wish to express grateful thanks to the great advisor Dr. K. M. Kulkarni (Former DE, Higher Education, Pune), the bird watcher and local expert M. H. Deshmukh who helped and supported for completion of this research paper during this study. Also the authors very much thanks to the forest and irrigation departments, Gondia to grant the permission for this research.

 

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Copyright: © 2016 | Author(s), This is an open access article under the terms of the Creative Commons Attribution-Non-Commercial - No Derivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.


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    INTERNATIONAL JOURNAL OF

    LIFE SCIENCES

    Print ISSN : 2320-7817 

    Online ISSN:2320-964X

    UGC Approved Journal No. 48951


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