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Published yearly: 

4 Issues


ISSN: 2320-964X (Online) 

ISSN: 2320-7817  (Print)



Dr. Santosh Pawar 




Int. Journal of Life Sciences, 2016; 4(4):509- 516   |    Available online, January 27, 2016

Role of Heat Shock Protein – 70 in the etiology of Idiopathic Pulmonary Arterial Hypertension



Chaitra KL1, Satyanarayana ML1, Vadapalli Shivani1, Manchineela Sairam, Bhukya Chaitanya Kumar, Sastry BKS2 and Nallari Pratibha1*

1Department of Genetics, Osmania University, Hyderabad – 500007

2Care Hospitals, Nampally, Hyderabad – 500001

*Corresponding Author: Prof. Pratibha Nallari, Department of Genetics, Osmania University,

Hyderabad – 500007  |  Email: | Ph. No: +91-8885486499

Received: 04.10.2016   |      Accepted: 04.11.2016       |         Published : 27.01.2017

Idiopathic Pulmonary Arterial Hypertension is a rare disorder that affects the pulmonary artery, whereby the pressure in the pulmonary artery is increased, culminating in overload on the right ventricle and eventually heart failure. Over the years many studies have been carried out to understand the etiology and to identify the appropriate treatment. This study attempts to contribute to the overall understanding of disease in relation with certain genes that are generally expressed under stress conditions, viz., the heat shock proteins (HSPs). Of this, a prominent group of proteins, HSP70, were identified, to establish a correlation with polymorphisms in these genes and any possible effect on IPAH.


Keywords: Idiopathic Pulmonary Arterial Hypertension, Heat shock proteins, single nucleotide polymorphisms, stress, chaperones



Editor: Dr. Arvind Chavhan


Cite this article as:

Chaitra KL, Satyanarayana ML, Vadapalli Shivani, Manchineela Sairam, Bhukya Chaitanya Kumar, Sastry BKS and Nallari Pratibha (2016) Role of Heat Shock Protein – 70 in the etiology of Idiopathic Pulmonary Arterial Hypertension, International J. of Life Sciences, 4 (4): 509-516.




The authors would like to acknowledge funding from PVRI-GSK, and UGC-RFSMS for fellowship to one of the authors. Author contributions: KLC carried out the study and wrote the paper, SV helped in collecting samples initially, MLS designed the primers, SM and CKM helped with insilico analysis, BKSS is the cardiologist who identified the patients, PN gave the idea for the study and insights to the paper.


Conflicts of interest: The authors stated that no conflicts of interest.



Copyright: © 2016 | Author(s), This is an open access article under the terms of the Creative Commons Attribution-Non-Commercial - No Derivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.


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