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Published yearly: 

4 Issues

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ISSN: 2320-964X (Online) 

ISSN: 2320-7817  (Print)

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Dr. Santosh Pawar 


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ORIGINAL ARTICLE

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Int. Journal of Life Sciences, 2017; 5(1):97- 101    |    Available online, 11 April, 2017

In vitro antifungal activity of ketoconazole against clinical isolates of Candida and Cryptococcus spp.

Ukesh CS* and Patil SD 



Dept of Microbiology, Shri Shivaji Science College, Amravati. 444 603 (M.S.) INDIA *Corresponding author Email: cswadekar@gmail.com | Mobile: +91-9421819027

Received: 13.01.2017        |     Accepted: 15.02.2017    |       Published : 11.04.2017

The incidence of fungal infections has been rising over the past few decades contributing to morbidity and mortality. Antifungal activity of ketoconazole was evaluated against clinical isolates of Candida abicans, C. guilliermondii, C. krusei, C. glabrata, C. parapsilosis, C. stellatoidea, C. tropicalis, C. pseudotropicalis and Cryptococcus neoformans by broth macrodilution, broth microdilution and agar dilution methods. Ketoconazole showed strong antifungal activities against isolated strains of Candida and Cryptococcus. Ketoconazole effectively inhibited C. albicans in the MIC range of 1.25-80 μg/ml by broth micro dilution, 2.5-160 μg/ml by broth macro dilution and 2.5-160 μg/ml by agar dilution method. Candida spp were more resistant to ketoconazole than Cryptococcus neoformans, as C. neoformans was inhibited at lower MIC range of 1.25-40 μg/ml. Agar dilution method showed higher MIC values as compared to broth dilution. The results suggest promising antifungal properties of ketoconazole. 


Key words: Antifungal activity, Ketoconazole, Susceptibility testing

 

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Editor: Dr. Arvind Chavhan

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Cite this article as:

Ukesh CS and Patil SD (2017) In vitro antifungal activity of ketoconazole against clinical isolates of Candida and Cryptococcus spp International J. of Life Sciences, 5 (1): 97-101.

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Conflicts of interest: The authors stated that no conflicts of interest.

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Copyright: © 2017 | Author(s), This is an open access article under the terms of the Creative Commons Attribution-Non-Commercial - No Derivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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