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Life Sciences

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Published yearly: 

4 Issues

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ISSN: 2320-964X (Online) 

ISSN: 2320-7817  (Print)

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Editor-in-Chief

Dr. Santosh Pawar 


INDEXED IN

ORIGINAL ARTICLE

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Int. Journal of Life Sciences, 2017; 5(1): 107- 110    |    Available online, 11 April, 2017

Inhibition of DMBA induced carcinogenesis in albino mice by Withania somnifera extracts

Amirtham S and Settu  A*

 

 

Medicinal plants Research Unit, P.G. Research Department of Botany, Govt. Arts and Science College, Ariyalur, Tamilnadu, India.

*Corresponding Author

Received: 09.02.2017    |   Accepted: 21.03.2017    |    Published : 11.04.2017

Cancer is one of the leading deaths causing disease in the world. Now a days, there are number of studies were conducted in order to eradicate cancer in the environment. From Ancient times, the medicinal plants used to treat cancer were found in different medicinal system in different parts of the world. The present study concentrates to find out the anticancer activity of medicinal plant named Withaniasomniferaagainst DMBA induced carcinogenesis in albino mice. Inorder to find the activity of the medicinal plant both invitro and invivo studies were conducted and the results confirmed that the ashwagandha has the anticancer activity and the aqueous root extract of ashwagandha had more potential when compared to the other extracts of the plant.

 

Keywords: Ashwagandha, DMBA, MTT assay, in-vivo studies

 

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Editor: Dr. Arvind Chavhan

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Cite this article as:

Amirtham S and Settu  A (2017) Inhibition of DMBA induced carcinogenesis in albino mice by Withania somnifera extracts, International J. of Life Sciences, 5  (1): 107-110

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Conflicts of interest: The authors stated that no conflicts of interest.

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Copyright: © 2017 | Author(s), This is an open access article under the terms of the Creative Commons Attribution-Non-Commercial - No Derivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Kataria H, Gupta M, Lakhman S, Kaur G (2015) Withaniasomnifera aqueous extract facilitates the expression and release of GnRH: In vitro and in vivo study. Neurochemistry International., 1-9.


Joshi P, Misra L, Siddique AA, Srivastava M, Kumar S, Darokar MP (2014) Epoxide group relationship with cytotoxicity in withanolide derivatives from Withaniasomnifera. Steroids. 19-27.


Jai Prakash J,  Gupta SK, Kochupillai V,  Singh N,  Gupta YK,  Joshi S (2001) Chemopreventive Activity of Withaniasomniferain Experimentally Induced FibrosarcomaTumours in Swiss Albino Mice. Phytother. Res., 15: 240–244.


Davis L, Kuttan G (2001) Effect of Withaniasomnifera on DMBA induced carcinogenesis. J. Ethanophar. 2001. 75: 165-168.


Barnes DA, Barlow R, Nigam PS, Owusu-Apenten (2016) Antioxidant, Anticancer and Antibacterial activity of Withaniasomnifera Aqueous root extract. J. advan in Bio & Biotech. 5(1): 1-6.


Yadav B, Bajaj A, Saxena M, Saxena AK (2010) In-vitro anticancer activity of the root, stem and leaves of Withaniasomnifera against various human cancer cell lines. Ind. J. Pharma Sci., 600-663.


Jayaprakasam B, Zhang Y, Seeram NP, Nair MG (2003) Growth inhibition of human tumor cell lines by withanolides from Withaniasomnifera leaves. Life sciences., 74: 125-132.


Christina AJM, Joseph DG, Packialakshmi M, Kathai R, Herison Robert SJ, Chidambaranathan N, Ramasamy M (2004) Anticarcinogenic activity of Withaniasomnifera Dunal against Dalton’s ascitic Lymphoma. J. Ethanophar., 93: 359-361.


Mathur R, Gupta SK, Singh N, MathurS,Kochupillai V, Velpandian T (2006) Evaluation of the effect of Withaniasomniferaroot extracts on cell cycle and angiogenesis. J. Ethanophar. 2006. 105:336-341.


Rathnasamy S, Auxilia LF, purusothaman (2014) Comparative studies on isolation and characterization of allinase from garlic and onion using PEGylation-A novel method. Asi. j. chem., 26: 3733-3735 (12).


Sundaramoorthy M, Prabakaran C, Purusothaman B, Saravanan TS (2014) Antibacterial and wound healing effects of semi purified heart proteins from certain selective slaughter house animals. Indoamerican J. Pharma. Res..4(01).


Balakrishnan P, Musafargani TA, subrahmanyam S, Shanmugam K (2015) A perspective on bioactive compounds from Solanumtrilobactum. J. Chem and Pharma. Res., 7(8): 507-512.

 

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    INTERNATIONAL JOURNAL OF

    LIFE SCIENCES

    Print ISSN : 2320-7817 

    Online ISSN:2320-964X

    UGC Approved Journal No. 48951


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