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Published yearly: 

4 Issues

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ISSN: 2320-964X (Online) 

ISSN: 2320-7817  (Print)

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RESEARCH ARTICLE

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Int. Journal of Life Sciences, 2018; 6(1): 117-122       |                 Available online, March 04, 2018

ACE Gene I/D Polymorphism-A Global Perspective in relation to Indian Population

 

Sheebanancy K1, Maheswari C1, Usha Raja Nanthini A1 *

 

 

1Department of Biotechnology, Mother Teresa Women’s University, Kodaikanal, Tamil Nadu, India.

*Corresponding author, E mail: biotechurn@gmail.com

Received : 14.12.2017    |     Accepted : 28.02.2018      |     Published : 04.03.2018

Alu elements are a family of interspersed repeats in the human genome. Alu ACE insertion (I)/deletion (D) polymorphism is a marker useful to study the genomic diversity of worldwide population. The genomic diversity among the populations may help to understand the evolutionary and migrational history of population. The present investigation is to examine the allele and genotype frequency of three population of south India- Paliyar tribe, Nadar and Pallar. Accurately, 147 samples were collected and genotype was done using PCR-SSP.  According to Hardy-Weinberg equilibrium equation, there have no significant difference in Pallar and Nadar population whereas, significant difference was observed in Paliyar tribe population (p-0.0001). The results of phylogenetic tree analysis and PCA showed that south Indian Paliyar tribal population separated from other population in India.  It might be due to under selection pressure.

 

Keywords:  ACE gene, Caste and tribe, South India, Phylogenetic analysis

 

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Editor: Dr.Arvind Chavhan

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Cite this article as:

Sheebanancy K, Maheswari C, Usha Raja Nanthini A (2018) ACE Gene I/D Polymorphism-A Global Perspective in relation to Indian Population, Int. J. of. Life Sciences, Volume 6(1): 117-122. 

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Conflicts of interest: The authors stated that no conflicts of interest.

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Copyright: © 2018 | Author(s), This is an open access article under the terms of the Creative Commons Attribution-Non-Commercial - No Derives License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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