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Published yearly: 

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ISSN: 2320-964X (Online) 

ISSN: 2320-7817  (Print)



Dr. Santosh Pawar 




Int. Journal of Life Sciences, 2018; 6(1):41-48       |                  Available online, February 24, 2018

Association of SH2B3 (rs3184504) polymorphism in essential hypertensive patients in south Indian population

Jayaseelan Vijayashree Priyadharsini1, Muthusamy Karthikeyan2, Venkatraman Shridevi3, Arumugam Paramasivam4, Gopalswamy Jayaraman5, Thiagarajan Santhiya Sathiyavedu5*



1Central Research Laboratory, Meenakshi Ammal Dental College and Hospital, Meenakshi Academy of Higher Education and Research, Maduravoyal, Chennai-95.   | 2Department of Bioinformatics, ​​Alagappa University, Karaikudi–630004, Tamil Nadu, India.   |    3IIIT-Hyderabad, Gachibowli, Hyderabad, Telangana 500032,

4Centre for Cellular and Molecular Biology, Hyderabad -500007, Telangana, India

5Department of Genetics, Dr.ALM PGIBMS, University of Madras, Taramani, Chennai-113, Tamil Nadu, India.

Corresponding author: E-mail ID:  |+91-9444460454

Received : 14.10.2017   |   Accepted : 04.02.2018    |     Published : 24.02.2018

Introduction: Essential hypertension (EH) is considered to be the major risk factor associated with cardiovascular, cerebrovascular and renal diseases. Molecular target identification is the key to the development of drug targets. SNP profiling is a basic method which provides insights into targets associated with disease phenotype. The present study is a case control model used to associate EH with one of the promising cell signalling marker SH2B3 expressed in inflammatory conditions. 


Results: The subjects recruited for the study were genotyped for rs3184504 polymorphism of SH2B3 gene. Female subjects with CC genotype were 1.4 times more susceptible to EH than male subjects. A significant association was observed for CC genotype on adjusting BMI (p value = 0.030, OR = 1.455, 95% CI = 1.036 – 2.042) in females. Consequently, the C vs T allele comparison in additive model also showed a significant difference (p value = 0.023, OR = 1.455, 95% CI = 1.036 – 2.042).


Conclusion: Although, several drugs have been developed for combating EH, the incident rate of the disease seems to rise over the past few decades. This fact clearly describes the ineffectiveness of current drugs to control BP and lack of awareness among individuals about the available treatment modalities. Personalized medicine designed to match the physiological conditions of the patient based on his genotype could safely and effectively control the disease. In this context, the SH2B3 (rs3184504) polymorphism is considered to be a significant marker associated with EH in south Indian population especially in female subjects.


Keywords: Essential hypertension, SH2B3, SNP, ARMS-PCR, Sequencing.



Editor: Dr.Arvind Chavhan


Cite this article as:

Jayaseelan Vijayashree Priyadharsini, Muthusamy Karthikeyan, Venkatraman Shridevi, Arumugam Paramasivam, Gopalswamy Jayaraman, Thiagarajan Santhiya Sathiyavedu(2018) Associa-tion of SH2B3 (rs3184504) polymerphi-sm in essential hypertensive patients in south Indian population, Int. J. of. Life Sciences, Volume 6(1): 41-48. 


Conflicts of interest: The authors stated that no conflicts of interest.



Copyright: © 2018 | Author(s), This is an open access article under the terms of the Creative Commons Attribution-Non-Commercial - No Derives License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.


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