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Published yearly: 

4 Issues

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ISSN: 2320-964X (Online) 

ISSN: 2320-7817  (Print)

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RESEARCH ARTICLE

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Int. Journal of Life Sciences, 2018; 6(2):569-574      |                 Available online, April 26, 2018

Anti-inflammatory potential of flavonoids from Hemigraphis colorata


Shahid Adangampurath and Sudheesh sudhakaran*

 

School of Chemical Sciences, Swami Ananthatheertha Campus, Kannur University

*Corresponding author email: sudheeshatl@yahoo.co.uk

Received : 05.02.2018 | Accepted : 23.03. 2018 | Published : 26.04.2018

Agents that inhibit inflammatory mediators are highly recommended in the development of anti-inflammatory drugs. Flavonoids are  large class of secondary metabolites around 10,000 structures, possess anti-inflammatory and various other properties which are valuable to human beings. In this study, different fractions of Hemigraphis colorata were collected based on increasing polarity and quantified the flavonoid content. Anti-inflammatory property was evaluated both in vitro and in vivo method. The chloroform fraction possess highest amount of flavonoid,  6.66 µg/100 µg sample. In the in vitro experiment acetone fraction possess maximum activity. In the in vivo experiment, acetone extract showed 43% and 48% of inhibition at 250 & 500 mg/kg b.wt. respectively against carrageenan induced paw oedema, while standard anti-inflammatory Diclophenac(10mg/Kg) exhibit 52.5 % inhibition.

 

Key words : Hemigraphis colorata, flavonoids, anti-inflammatory, diclophenac

 

 

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Editor: Dr.Arvind Chavhan

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Cite this article as:

Shahid Adangampurath and Sudheesh sudhakaran (2018) Anti-inflammatory potential of flavonoids from Hemigraphis colorata, Int. J. of. Life Sciences, Volume 6(2): 569-574. 

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Acknowledgement

I thank University Grants Commission, Western Region, Pune, India for providing the financial support. I also thank the College for providing the laboratory facilities.

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Conflicts of interest: The authors stated that no conflicts of interest.

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Copyright: © 2018 | Author(s), This is an open access article under the terms of the Creative Commons Attribution-Non-Commercial - No Derives License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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