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Published yearly: 

4 Issues

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ISSN: 2320-964X (Online) 

ISSN: 2320-7817  (Print)

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Dr. Santosh Pawar 


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RESEARCH ARTICLE

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Int. Journal of Life Sciences, 2018; 6(4): 895-904      |                 Available online, December 22, 2018

In-vitro evaluation of antiproliferative activity of Cymbopogon citratus (lemon grass) against lung cancer

 

Mallikarjunaiah Shanthala, Pattabhiramaiah Mahesh*, Maimom Preety, Chaitra GS and Diwan Nupur

 

Centre for Applied Genetics, Department of Zoology, Bangalore University, Bangalore-, 560056, India

*Corresponding author Dr. P.Mahesh, Centre for Applied Genetics,Department of Zoology, Bangalore University, Bangalore, 560056, India

Email :dr.pmahesh@gmail.com   |   Phone : 9916130942

 

 

Received: 25.01.2018    |   Revised: 07.04.2018   |  Accepted: 03.12.2018   |   Published: 22.12.2018

The present study describes the phytochemical and anticancer activity of Cymbopogon citratus (Lemon grass) extracts on lung cancer CALU6 cell line. The phytochemical analysis revealed that Cymbopogon citratus consists of alkaloids, tannins, terpenoids, saponins and flavanoids. The antiproliferative activity of C. citratus exhibited an IC50 value of 134.0µg/ml on lung cancer CALU6 cell line. The gene expression study was conducted on caspase 3, caspase 8 & β actin revealed that C. citratus was found to suppress the expression of Caspase-3 and Caspase-8 genes but is more effective in the treatment of lung cancer because of inhibition of cell proliferation occurred through Caspase-independent pathway.

 

Key words: Cymbopogon citratus, CALU6 cell line, phytochemicals, antiproliferative activity, Caspases.

 

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Editor: Dr.Arvind Chavhan

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Cite this article as:

Mallikarjunaiah Shanthala, Pattabhiramaiah Mahesh, Maimom Preety, Chaitra GS and Diwan Nupur (2018) In-vitro evaluation of antiproliferative activity of Cymbopogon citratus (lemon grass) against lung cancer. Int. J. of. Life Sciences, Volume 6(4): 895-904. 

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Conflicts of interest: The authors stated that no conflicts of interest.

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Copyright: © 2018 | Author(s), This is an open access article under the terms of the Creative Commons Attribution-Non-Commercial - No Derives License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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